Alpha Innotech

Microarray

Designed exclusively for high throughput reading of microarrays, AlphaArray™ Reader provides unmatched sensitivity, speed of acquisition, data integrity, dependability and flexibility in functional genomics, proteomics, gene expression and drug discovery research.

AlphaArray™ Reader Microarray Applications

	Cancer/Oncology Research
	Cell Arrays
	DNA Microarrays
	Drug Discovery Research
	FISH Analysis

	Gene Expression Studies
	Gene Mapping
	Genetic Disease Studies
	Genetic Screening
	Genomics Research

	Genotyping
	High Throughput Screening
	Immunohistochemistry
	Infectious Disease Studies
	Microplate Assay Analysis

	Pharmacogenomics
	Protein Microarrays
	Proteomics Research
	Sequencing by Hybridization (SBH)
	SNP Analysis
	Toxicology Studies

Blazing Data Acquisition Speed
AlphaArray™ Reader gathers the emission signal from the entire sample in real time compared to PMT/laser technologies that have to excite and scan each pixel separately.
	Current Limitation Scan from a typical laser/PMT device: 60 sec. acquisition time, 16mm x 22mm array, Cy3 labeled slide. (CLONTECH Atlas Glass Human 1.0K Microarray, catalog#7900-1, www.clontech.com)
	AlphaArray™ Reader Innovation Same Cy3 labeled slide capture with AlphaArray™: Reader 1.5 sec. acquisition time, 16mm x 22mm array. NovaRay™ Light Management System technology reduces comparable acquisition time by 10-100 fold.

Unrivaled Sensitivity

AlphaArray™ Reader provides exceptional sensitivity for even the most demanding applications. Designed around the unique NovaRay™ Light Management System, AlphaArray™ Reader simultaneously provides real time light collection of the entire two dimensional sample with over one million pixels which increases sensitivity while maintaining precise data consistency. Unlike confocal optical systems that only give a thin slice, the AlphaArray™ Reader collects all the fluorescence. AlphaArray™ Reader achieves sensitivities greater than 0.06 fluor/micron(2).

Powerful Image Acquisition and Analysis Tools Provide Unequaled Data Integrity
The inherent hardware and software design technology incorporated into AlphaArray Reader generates superior image quality, details, linear dynamic range, and reproducible results. Moreover, with the ArrayEase™ software data analysis is a snap with automatic grid alignment, spot detection, and background correction. Alpha Innotech Corporation’s extensive experience in developing signal detection algorithms with easy workflow allows users to automatically align, detect, and background correct spots with a single button click as well as allowing for quick and easy individual spot data display.
	Current Limitation Line plot of Cy3 labeled slide scanned with a laser/PMT device. Note how the noise and scatter in signal intensity appears as “cavities” in the profile.
	Imaging Innovation Line plot of identical slide read by AlphaArray™. Reader. The NovaRay™ Light Management System collects all of the fluorescence to deliver smooth, solid quantitative performance.

Integrated Ease of Use

Data acquisition is a breeze with an automated and intuitive software workflow designed into the ArrayEase™ software.

	Automatic image exposure and focus modes select the proper scan time and focal plane depth with a single button click.
	Customized templates for image acquisition settings allow you to automatically configure the system for precise and reproducible results for multiple experimental settings.

Reliable High Throughput

AlphaArray™ Reader provides reliable high throughput performance for the most demanding of requirements. With the ability to process hundreds of slides per day with batch operations and bar code reading, the ArrayEase™ software package provides extensive tools for automating multiple sample operation while ensuring accuracy and reproducible results. The removable sample tray holds multiple slides without the risk of slide jams that can occur with cartridge based autoloading technologies.

Full Spectrum of Sample Labeling Choices
Hundreds of combinations of dyes can be read with 8 different broad excitation wavelengths all designed around the NovaRay™ Light Management System. AlphaArray™ is capable of supporting the following common fluorescent dyes, while custom emission filters can be provided for emerging dye choices as required:
Cy3 Cy5 Cy3.5 Cy5.5 FITC Alexa 488, 532, 546, 594 BODIPY 630/650	FAM JOE ROX TAMRA Tetramethyl Rhodamine Texas Red and many more...

Exceptional Resolution and Dynamic Range

The AlphaArray™ Reader is a 16-bit (0 - 65,535 grayscale range) system that acquires data with exceptional resolution and dynamic range for all array exposure times. The near real time dynamic display feature generates a high resolution, high dynamic range image every time at blazing acquisition speeds.

Unmatched Sample Format Versatility

Reading a variety of sample formats is a standard capability of AlphaArray™ Reader. The removable sample holder tray of AlphaArray™ Reader can accommodate up to twelve 1" x 3" slides with varying thickness or dimensions. Optional sample holders can accommodate larger slides or plate based assay formats as well. The AlphaArray™ Reader is compatible with all commercially available slides and custom arrays.

Advanced Database Capabilities

Our graphical reporting tools provide the ability to view or export data in easy to understand statistical reports and formats. The ArrayEase™ Software imaging software has several data reporting views for data results, spot plots, intensity histograms, and scatter plots that can be exported to databases in user defined table formats. Also, the database engine of ArrayEase™ Software provides smooth and flexible interaction with downstream data migration, visualization, and data mining requirements. User driven data selection finds the crucial data and delivers presentation ready results. In addition, ArrayEase™ Software is integrated with web accessible databases. By entering a URL or importing a preferred URL with an array list, your default web browser will open the genomics database and automatically search the database for information about your selected sample.

Dependability You Can Count On

The core technology incorporated into AlphaArray™ Reader is reliable and robust even in the most rigorous environments. AlphaArray™ Reader ELIMINATES the necessity to repair expensive lasers or perform optical alignments required with other scanners. Also, the advanced design of AlphaArray™ Reader ELIMINATES uneven scans due to laser power fluctuations or x, y stage pixel by pixel registration variations. The AlphaArray™ Reader delivers the reliability to rapidly achieve your genetic discovery goals.

*AlphaArray™ Reader is protected by intellectual property rights owned by Alpha Innotech Corporation. Patents and other intellectual property rights held by others may cover certain microarrays or arrays and/or their methods of preparation or use of analysis. Alpha Innotech Corporation does not encourage or support the unauthorized or unlicensed use of any technology or intellectual property. Use of Alpha Innotech Corporation products is recommended only when the end user has a license under proprietary rights of third parties for the relevant technology or for technology that does not require a license. Alpha Innotech Corporation does not provide legal advice; end users should consult their institution’s legal department.

US patent #6,271,042

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